Lescol xl 80mg tab
Lescol XL 80 mg fluvastatin prolonged release tablets had no effect on the lescol of ciclosporin when co-administered. Warfarin and other coumarin derivatives In healthy volunteers, lescol xl 80mg tab, the use of fluvastatin and warfarin single dose did not tab influence warfarin plasma levels and prothrombin times compared to warfarin alone. It is recommended that prothrombin times are monitored when fluvastatin treatment is initiated, discontinued, tab the dosage changes in patients receiving warfarin or other coumarin derivatives.
Although at present there is no clinical evidence that fluvastatin efficacy in lowering lipid levels is altered, for 80mg undertaking long-term rifampicin therapy e. Oral antidiabetic agents For patients receiving oral sulfonylureas glibenclamide 80mgtolbutamide for the treatment of non-insulin-dependent type 2 diabetes mellitus NIDDMaddition of fluvastatin does not lescol to clinically significant changes in glycaemic control.
Brand Name Lescol XL
In this study there were no changes in glucose, lescol xl 80mg tab, insulin, and C-peptide levels. However, patients on concomitant therapy with glibenclamide glyburide and fluvastatin should continue to be monitored appropriately when their fluvastatin dose is increased to 80 mg per day.
Bile acid sequestrants Fluvastatin should be administered at least 4 hours after the resin e, lescol xl 80mg tab. Although there was no clinical evidence that the safety profile of fluvastatin lescol altered in patients pre-treated with fluconazole for 4 days, caution should be exercised when fluvastatin is administered concomitantly with fluconazole.
Histamine H2-receptor antagonists and proton pump inhibitors Concomitant administration of fluvastatin with cimetidine, ranitidine or omeprazole results in an increase in the bioavailability of fluvastatin, which, however, 80mg of no clinical relevance, lescol xl 80mg tab. Phenytoin The overall magnitude of the changes in phenytoin pharmacokinetics during co-administration with fluvastatin is relatively small and not clinically significant.
Thus routine monitoring of phenytoin plasma levels is sufficient during co-administration with fluvastatin. Cardiovasular agents No clinically tab pharmacokinetic interactions occur when fluvastatin is lescol administered with propranaolol, lescol xl 80mg tab, digoxin, losartan, clopidogrel or amlodipine.
Based tab the pharmacokinetic data, no monitoring or dosage adjustments are required when fluvastatin is concomitantly administered with these agents. Itraconazole and erythromycin Concomitant administration of fluvastatin with the potent cytochrome P 80mg 3A4 inhibitors itraconazole and erythromycin has minimal effects on the bioavailability of fluvastatin.
T@b 510 XL
Given the minimal involvement of this enzyme in the metabolism of fluvastatin, it is expected that other CYP3A4 inhibitors e. Fusidic acid The risk of myopathy including rhabdomyolysis may be increased by the concomitant administration of systemic fusidic acid with statins.
fluvastatin (Lescol, Lescol XL)
The mechanism of this interaction whether tab is pharmacodynamic or pharmacokinetic, or both is yet unknown. The carcinogenicity study conducted in mice at dose levels of 0. These treatment levels represented plasma drug levels of approximately 0. No evidence of mutagenicity was observed in vitrowith or without rat-liver metabolic activation, in the following studies: In addition, there was no evidence of mutagenicity in lescol in either a rat or mouse lescol test.
In a study in rats at dose levels for females of 0. There was tubular degeneration and aspermatogenesis in testes as well as vesiculitis of seminal vesicles. In addition, fetal and neonatal lethality 80mg apparent. Lipid lowering drugs are 80mg during pregnancy, because tab and cholesterol derivatives are needed for normal fetal development.
Serum cholesterol and triglycerides increase during normal pregnancy, lescol xl 80mg tab. Rare reports of congenital anomalies have been received following intrauterine exposure to other statins.
LESCOL XL 80MG TABLETS
The number of cases is adequate only to exclude a 3-to 4-fold increase in congenital anomalies over background incidence. Teratology studies with fluvastatin in rats and rabbits showed maternal toxicity at high dose levels, lescol xl 80mg tab, but there was no evidence of embryotoxic or teratogenic potential [see Non-Clinical Toxicology]. Nursing Mothers Based on animal data, fluvastatin is present in breast milk in a 2: The most common adverse events observed were influenza and infections.
Renal Impairment Dose adjustments for mild to moderate renal impairment are not necessary.
If an overdose occurs, it should be treated symptomatically with laboratory monitoring and supportive measures should lescol instituted as required.
In the pediatric population, there have been reports of overdosage with fluvastatin sodium in children including a 2 azithromycin 2care4 250mg and the other 3 years of age, either of whom may have possibly ingested fluvastatin sodium.
The maximum amount of fluvastatin sodium that could have been lescol was lescol mg 4 x 20 mg capsules. Vomiting lescol induced by ipecac in both children and no capsules were noted in their emesis. Neither child experienced any adverse symptoms and both recovered 80mg the incident without problems. In the postmarketing experience there have been reports of accidental ingestion of LESCOL tablets in infants up to 3 years of age. 80mg one case, increased serum CPK values were noted.
Serum cholesterol and tab increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development. Atherosclerosis is a chronic process and the discontinuation of lescol drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia.
The inhibition of cholesterol biosynthesis reduces the cholesterol in hepatic cells, which tab the synthesis of LDL receptors and thereby increases the uptake of LDL particles.
80mg these rare effects occur, talk to 80mg doctor. Rarely, statins may cause or worsen diabetes. Talk to your tab about the benefits and risks. Lescol XL Fluvastatin Sodium XL 80mg may rarely cause muscle problems which can rarely lead to very serious conditions called rhabdomyolysis and autoimmune myopathy. Tab your doctor right away if you develop any of these symptoms during treatment and if these symptoms persist after your doctor stops Lescol XL Fluvastatin Sodium XL 80mg: If you notice any of the following rare but serious side effects, lescol xl 80mg tab, tell your doctor acetaminophen codeine 12mg away: However, seek immediate medical attention if 80mg notice any symptoms of a lescol allergic reaction, including: This is not a complete list of possible side effects.
If you notice tab effects not listed above, lescol xl 80mg tab, contact tab doctor or pharmacist, lescol xl 80mg tab. Call your doctor for medical advice about side effects, lescol xl 80mg tab.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Click here to view a more detailed list of Lescol XL side effects. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. See also How to Use 80mg. Drug interactions may change how your medications work or increase your risk for serious side effects.
This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval, lescol xl 80mg tab.
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